Genetic Linkage Analysis and Age-Of-Onset Correction
نویسندگان
چکیده
منابع مشابه
Heritability and linkage analysis of appendicitis utilizing age at onset.
Appendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromo...
متن کاملThe additive genetic gamma frailty model for linkage analysis of age-of-onset variation.
Age of onset is a key factor in the linkage analysis of many complex diseases. Current methods in nonparametric linkage analysis are mainly concentrated on the affected relative pairs or affected family members with age of onset information either ignored or taken into account by specifying age-dependent penetrances for liability classes. On the other hand, gamma frailty models were developed i...
متن کاملLinkage analysis for diseases with variable age of onset.
We present a method for the multivariate linkage analysis of the age of onset of a disease. The approach allows the incorporation of covariates for the study of gene by environment interactions. It is applicable to general pedigrees. The likelihood of the data is expressed as a function of the number of alleles identical by descent at a marker, the censored ages of onset and disease status, and...
متن کاملScore test for age at onset genetic linkage analysis in selected sibling pairs.
A new score statistic is derived, which uses information from registries (age-specific incidences) and family studies (sib-sib marginal correlation) to weight affected sibling pairs according to their age at onset. Age at onset of sibling pairs is modelled by a gamma frailty model. From this model we derive a bivariate survival function, which depends on the marginal survival and on the margina...
متن کاملRobust age at onset linkage analysis in nuclear families.
OBJECTIVE Standard methods for linkage analysis ignore the phenotype of the parents when they are not genotyped. However, this information can be useful for gene mapping. In this paper we propose methods for age at onset genetic linkage analysis in sibling pairs, taking into account parental age at onset. METHODS Two new score statistics are derived, one from an additive gamma frailty model a...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1982
ISSN: 0007-1250,1472-1465
DOI: 10.1017/s0007125000112899